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Startseite Röblitz, Susanna, Prof. Dr.

Röblitz, Susanna, Prof. Dr.

Kontakt

Position
Gast
Raum
4106
Telefon
+49 30 84185-156
E-Mail
E-Mail
Website
https://www.zib.de/userpage/susanna.roeblitz/
Bereich
Mathematics of Complex Systems
Abteilung
Modeling and Simulation of Complex Processes
Arbeitsgruppe
Computational Systems Biology

Projekte

Projekte als Leitung

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Empirical Bayes methods in systems medicine

One of the main goals of mathematical modeling related to medical applications is to obtain patient-specific parametrizations and model predictions. In clinical practice...

Empirical Bayes methods in systems medicine
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Modelling Inflamed Arthritic Joints

The purpose of the project is the development of an in vitro and in silico model for arthritis research in order to reduce the use of laboratory animals for in vivo...

Modelling Inflamed Arthritic Joints
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Uncertainty Quantification for Bayesian Inverse Problems with Applications to Systems Biology

This research is carried out in the framework of MATHEON supported by Einstein Foundation Berlin.

Uncertainty Quantification for Bayesian Inverse Problems with Applications to Systems Biology
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Model Classification under Uncertainties for Cellular Signalling Networks

This research is carried out in the framework of MATHEON supported by Einstein Foundation Berlin.

Model Classification under Uncertainties for Cellular Signalling Networks

Projekte als Mitglied

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Uncertainty Quantification for Bayesian Inverse Problems with Applications to Systems Biology

This research is carried out in the framework of MATHEON supported by Einstein Foundation Berlin.

Uncertainty Quantification for Bayesian Inverse Problems with Applications to Systems Biology
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Mathematical Modeling of BMP Mediated Cellular Signaling Pathways

Bone morphogenetic proteins (BMPs) belong to the TGFβ superfmily of proteins, and are known to be associated with essential biological processes such as embryogenesis and...

Mathematical Modeling of BMP Mediated Cellular Signaling Pathways
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Mathematical Modelling of Tuberculosis in Cameroon

Tuberculosis (TB) is a preventable and curable disease caused by Mycobacterium tuberculosis (Mtb) that most often affects the lungs. Mtb’s infection can remain latent...

Mathematical Modelling of Tuberculosis in Cameroon
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Kinetics and Design of Multivalent Processes

Binding of a multivalent ligand to a multivalent receptor consists of kinetically different elemetary steps. The first binding event is an intermolecular process, whereas...

Kinetics and Design of Multivalent Processes

Publikationen

2024
Spectral clustering of Markov chain transition matrices with complex eigenvalues Journal of Computational and Applied Mathematics, Vol.444, p. 115791, 2024 Anna-Simone Frank, Alexander Sikorski, Susanna Röblitz BibTeX
arXiv
DOI
2022
Hormonal regulation of ovarian follicle growth in humans: Model-based exploration of cycle variability and parameter sensitivities Journal of Theoretical Biology, 2022 Sophie Fischer-Holzhausen, Susanna Röblitz BibTeX
DOI
Mathematical modelling of follicular growth and ovarian stimulation Current Opinion in Endocrine and Metabolic Research, 2022 Sophie Fischer-Holzhausen, Susanna Röblitz BibTeX
DOI
Model Based Exploration of Hypokalemia in Dairy Cows Scientific Reports, Vol.12, 19781, 2022 Julia Plöntzke, Mascha Berg, Rainald Ehrig, Sabine Leonhard-Marek, Kerstin-Elisabeth Müller, Susanna Röblitz BibTeX
DOI
The androgen system across the menstrual cycle: Hormonal, (epi-)genetic and psychometric alterations Physiology and Behavior, 2022 Tillmann Krüger, Brigitte Leeners, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Harald Engler, Susanna Röblitz, Helge Frieling, Christopher Sinke, Kirsten Jahn BibTeX
DOI
2021
Modelling Oscillatory Patterns in the Bovine Estrous Cycle with Boolean Delay Equations Bulletin of Mathematical Biology, 83(121), pp. 1-25, 2021 Mascha Berg, Julia Plöntzke, Heike Siebert, Susanna Röblitz BibTeX
DOI
Objective priors in the empirical Bayes framework Scandinavian Journal of Statistics, 48(4), pp. 1212-1233, 2021 Ilja Klebanov, Alexander Sikorski, Christof Schütte, Susanna Röblitz BibTeX
DOI
2020
Model-based exploration of the impact of glucose metabolism on the estrous cycle dynamics in dairy cows Biology Direct, Vol.15, 2020 Mohamed Omari, Alexander Lange, Julia Plöntzke, Susanna Röblitz BibTeX
DOI
2019
A Mathematical Model for the Influence of Glucose-Insulin Dynamics on the Estrous Cycle in Dairy Cows ZIB-Report 19-22 Mohamed Omari, Alexander Lange, Julia Plöntzke, Susanna Röblitz PDF
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A pharmacokinetic-pharmacodynamic model for single dose administration of Dexamethasone in dairy cows ZIB-Report 19-53 Mohamed Omari, Julia Plöntzke, Susanna Röblitz PDF
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Combining in vitro simulation and in silico modelling towards a sophisticated human osteoarthritis model Osteoarthritis and Cartilage, Vol.27, p. S183, 2019 Annemarie Lang, Lisa Fischer, Marie-Christin Weber, Timo Gaber, Rainald Ehrig, Susanna Röblitz, Frank Buttgereit BibTeX
DOI
In vitro and in silico modeling of cellular and matrix-related changes during the early phase of osteoarthritis BioRxiv, 2019 Marie-Christin Weber, Lisa Fischer, Alexandra Damerau, Igor Ponomarev, Moritz Pfeiffenberger, Timo Gaber, Sebastian Götschel, Jens Lang, Susanna Röblitz, Frank Buttgereit, Rainald Ehrig, Annemarie Lang BibTeX
DOI
Modeling of Multivalent Ligand-Receptor Binding Measured by kinITC Computation, 7(3), p. 46, 2019 Franziska Erlekam, Sinaida Igde, Susanna Röblitz, Laura Hartmann, Marcus Weber BibTeX
DOI
2018
A mathematical modelling approach to the insight of dynamic networks: Potassium homeostasis and glucose-insulin in dairy cows ADSA 2018 Annual Meeting, Vol.101 Suppl. 2, pp. 226-227, American Dairy Science Association, Journal of Dairy Science, 2018 Julia Plöntzke, Mascha Berg, Susanna Röblitz BibTeX
Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion, Workshop of the Federated Logic Conference 2018 (FLoC 2018), Oxford, pp. 1-16, 2018 Toni Mancini, Federico Mari, Annalisa Massini, Igor Melatti, Ivano Salvo, Stefano Sinisi, Enrico Tronci, Rainald Ehrig, Susanna Röblitz, Brigitte Leeners BibTeX
DOI
Correspondence of Trap Spaces in Different Models of Bioregulatory Networks SIAM Journal on Applied Dynamical Systems, 17(2), pp. 1742-1765, 2018 (preprint available as ZIB-Report 18-10) Robert Schwieger, Heike Siebert, Susanna Röblitz PDF (ZIB-Report)
BibTeX
DOI
Follicular competition in cows: the selection of dominant follicles as a synergistic effect Journal of Mathematical Biology, 2018 (preprint available as ZIB-Report 17-21) Alexander Lange, Robert Schwieger, Julia Plöntzke, Stefan Schäfer, Susanna Röblitz PDF (ZIB-Report)
BibTeX
DOI
Generalized Markov State Modeling Method for Nonequilibrium Biomolecular Dynamics: Exemplified on Amyloid β Conformational Dynamics Driven by an Oscillating Electric Field Journal of Chemical Theory and Computation, 14(7), pp. 3579-3594, 2018 Bernhard Reuter, Marcus Weber, Konstantin Fackeldey, Susanna Röblitz, Martin E. Garcia BibTeX
DOI
In silico Methods - Computational Alternatives to Animal Testing ALTEX, 35(1), pp. 126-128, 2018 Annemarie Lang, Andrea Volkamer, Laura Behm, Susanna Röblitz, Rainald Ehrig, Marlon Schneider, Lisbet Geris, Joerg Wichard, Frank Buttgereit BibTeX
DOI
2017
A dynamic model to simulate potassium balance in dairy cows Journal of Dairy Science, 100(12), pp. 9799-9814, 2017 (preprint available as ZIB-Report 17-47) Mascha Berg, Julia Plöntzke, Sabine Leonhard-Marek, Kerstin-Elisabeth Müller, Susanna Röblitz PDF (ZIB-Report)
BibTeX
DOI
Lack of association between female hormone levels and visuospatial working memory, divided attention and cognitive bias across two consecutive menstrual cycles Front. Behav. Neurosci., 2017 Brigitte Leeners, Tillmann H. C. Krüger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Lanja Saleh, K. Spanhaus, Cordula Schippert, Y. Zhang, M. P. Hengartner BibTeX
DOI
Linear Precision Glycomacromolecules with Varying Interligand Spacing and Linker Functionalities Binding to Concanavalin A and the Bacterial Lectin FimH Marcomolecular Bioscience, 17(12), p. 1700198, 2017 Sinaida Igde, Susanna Röblitz, Anne Müller, Katharina Kolbe, Sophia Boden, Claudia Fessele, Thisbe Lindhorst, Marcus Weber, Laura Hartmann BibTeX
DOI
Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle: evidence from a multisite observational study across two successive cycles Journal of Psychosomatic Research, Vol.99, pp. 21-27, 2017 Michael Hengartner, Tillmann H. C. Krüger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, Susanna Röblitz, Rainald Ehrig, Lanja Saleh, Katharina Spanaus, Cordula Schippert, Yuanyuan Zhang, Brigitte Leeners BibTeX
DOI
2016
An integrative approach for model driven computation of treatments in reproductive medicine BIOMAT - Proceedings of the 15th International Symposium on Mathematical and Computational Biology, Rorkee, India, 2016 (preprint available as ZIB-Report 16-04) Rainald Ehrig, Thomas Dierkes, Stefan Schäfer, Susanna Röblitz, Enrico Tronci, Toni Mancini, Ivano Salvo, Vadim Alimguzhin, Federico Mari, Igor Melatti, Annalisa Massini, Tillmann H. C. Krüger, Marcel Egli, Fabian Ille, Brigitte Leeners PDF (ZIB-Report)
BibTeX
Empirical Bayes Methods for Prior Estimation in Systems Medicine ZIB-Report 16-57 Ilja Klebanov, Alexander Sikorski, Christof Schütte, Susanna Röblitz PDF
BibTeX
URN
arXiv
Empirical Bayes Methods, Reference Priors, Cross Entropy and the EM Algorithm ZIB-Report 16-56 Ilja Klebanov, Alexander Sikorski, Christof Schütte, Susanna Röblitz PDF
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Follicular maturation in cows: mathematical models and data 10. European Conference on Mathematical and Theoretical Biology, 2016 Alexander Lange, Julia Plöntzke, Stefan Schäfer, Susanna Röblitz BibTeX
Mathematical Modelling of Follicular Maturation in Cows and Women 49. Jahrestagung der Physiologie und Pathologie der Fortpflanzung und gleichzeitig 41. Veterinär-Humanmedizinische Gemeinschaftstagung 2016, Leipzig., 2016 (epub ahead of print) Stefan Schäfer, Julia Plöntzke, Susanna Röblitz BibTeX
Modelling of glucose-insulin metabolism and its effect on the estrous cycle in bovine Annual Meeting of the Population Approach Group in Europe, 2016 Mohamed Omari, Julia Plöntzke, Mascha Berg, Susanna Röblitz BibTeX
Prior estimation and Bayesian inference from large cohort data sets ZIB-Report 16-09 Ilja Klebanov, Alexander Sikorski, Christof Schütte, Susanna Röblitz PDF
PDF
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2015
A guide to numerical modelling in systems biology Springer, 2015, ISBN: 978-3-319-20058-3 Peter Deuflhard, Susanna Röblitz BibTeX
DOI
A systems biology approach to bovine fertility and metabolism: Introduction of a glucose insulin model 15th International Symposium on Mathematical and Computational Biology, Rorkee, India, 2015 (preprint available as ZIB-Report 15-51) Julia Plöntzke, Mascha Berg, Claudia Stötzel, Susanna Röblitz PDF (ZIB-Report)
BibTeX
Complementing ODE-based System Analysis Using Boolean Networks Derived from an Euler-like Transformation PLOS ONE, 2015 (preprint available as ZIB-Report 15-46) Claudia Stötzel, Susanna Röblitz, Heike Siebert PDF (ZIB-Report)
BibTeX
DOI
Identifying Multivalent Binding Kinetics of Precision Glycomacromolecules: A Kinetic Study Using kinITC Münster Symposium on Cooperative Effects 2015 - SFB 858, at Westfälische Wilhelms-Universität Münster, 2015, 2015 Sinaida Igde, Hendrik Wölk, Susanna Röblitz, Marco Reidelbach, Marcus Weber, Laura Hartmann BibTeX
Parameter Identification in a Tuberculosis Model for Cameroon PLOS ONE, 2015 (preprint available as ZIB-Report 13-72) Dany Pascal Moualeu-Ngangue, Susanna Röblitz, Rainald Ehrig, Peter Deuflhard PDF (ZIB-Report)
BibTeX
DOI
Solution of the chemical master equation by radial basis functions approximation with interface tracking BMC Systems Biology, 9(67), pp. 1-12, 2015 Ivan Kryven, Susanna Röblitz, Christof Schütte PDF
BibTeX
DOI
2014
A reduced ODE model of the bovine estrous cycle ZIB-Report 14-33 Claudia Stötzel, Mochamad Apri, Susanna Röblitz PDF
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Advanced mathematical modeling in systems biology MATHEON-Mathematics for Key Technologies, Vol.1, pp. 29-44, Peter Deuflhard, Martin Grötschel, Dietmar Hömberg, Jürg Kramer, Volker Mehrmann, Konrad Polthier, Frank Schmidt, Christof Schütte, Martin Skutela, Jürgen Sprekels (Eds.), European Mathematical Society, 2014 Alexander Bockmayr, Heike Siebert, Susanna Röblitz, Christof Schütte, Peter Deuflhard BibTeX
Exploration of different wave patterns in a model of the bovine estrous cycle by Fourier analysis BIOMAT - Proceedings of the 14th International Symposium on Mathematical and Computational Biology, Bedlewo, Poland, 2014 (preprint available as ZIB-Report 16-02) Claudia Stötzel, Rainald Ehrig, H. Marike T. Boer, Julia Plöntzke, Susanna Röblitz PDF (ZIB-Report)
BibTeX
Mathematische Modellierung metabolischer Einflussfaktoren auf den Milchkuhzyklus Master's thesis, Humboldt-Universität zu Berlin, Susanna Röblitz, Caren Tischendorf (Advisors), 2014 Jane Knöchel PDF
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Modeling of the BMP mediated co-regulation of the Smad and Non-Smad pathways in the context of cell density 10th International BMP conference, 2014, Berlin, Germany, 2014 Pooja Gupta, Carola Krause, Paul Rikeit, Susanna Röblitz, Petra Knaus, Christof Schütte BibTeX
Patient-Specific Models from Inter-Patient Biological Models and Clinical Records Proceedings of the 14th Conference on Formal Methods in Computer-Aided Design (FMCAD 2014), pp. 207-214, 2014 Toni Mancini, Ivano Salvo, Federico Mari, Igor Melatti, Annalisa Massini, Stefano Sinisi, Enrico Tronci, Francesco Davi, Thomas Dierkes, Rainald Ehrig, Susanna Röblitz, Brigitte Leeners, Tillmann H. C. Krüger, Marcel Egli, Fabian Ille BibTeX
2013
A mathematical model of the human menstrual cycle for the administration of GnRH analogues Journal of Theoretical Biology, Vol.321, pp. 8-27, 2013 (preprint available as ZIB-Report 11-16) Susanna Röblitz, Claudia Stötzel, Peter Deuflhard, Hannah M. Jones, David-Olivier Azulay, Piet van der Graaf, Steven Martin PDF (ZIB-Report)
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Adaptive spectral clustering with application to tripeptide conformation analysis The Journal of Chemical Physics, Vol.139, pp. 110-194, 2013 Fiete Haack, Konstantin Fackeldey, Susanna Röblitz, Olga Scharkoi, Marcus Weber, Burkhard Schmidt BibTeX
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Fuzzy spectral clustering by PCCA+: application to Markov state models and data classification Advances in Data Analysis and Classification, 7(2), pp. 147-179, 2013 Susanna Röblitz, Marcus Weber BibTeX
DOI
Mathematical modeling of the Smad and Non-Smad BMP signaling pathways in context of cell density Computational Models in biology and medicine, 2013, Dresden, Germany, 2013 Pooja Gupta, Susanna Röblitz, Carola Krause, Petra Knaus, Christof Schütte BibTeX
Mathematische Modellierung der Knochenremodellierung ZIB-Report 13-41 Kristin Meisel, Susanna Röblitz PDF
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Modeling potassium balance in dairy cows ZIB-Report 13-09 Julia Plöntzke, Mascha Berg, Amiya Olany, Sabine Leonhard-Marek, Kerstin-Elisabeth Müller, Susanna Röblitz PDF
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Parameter identification in large kinetic networks with BioPARKIN CoRR - Computing Research Repository - arXiv.org, Vol.abs/1303.4928, 2013 Thomas Dierkes, Susanna Röblitz, Moritz Wade, Peter Deuflhard PDF
BibTeX
2012
A differential equation model to investigate the dynamics of the bovine estrous cycle Advances in Systems Biology, pp. 597-606, 2012 H. Marike T. Boer, Claudia Stötzel, Susanna Röblitz, Henri Woelders BibTeX
DOI
Advances in modelling of the bovine estrous cycle: Synchronization with PGF2alpha Theriogenology, Vol.78, pp. 1415-1428, 2012 (preprint available as ZIB-Report 11-17) Claudia Stötzel, Julia Plöntzke, Wolfgang Heuwieser, Susanna Röblitz PDF (ZIB-Report)
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DOI
Mathematical modeling of follicular development in bovine estrous cycles ZIB-Report 12-26 Manon Bondouy, Susanna Röblitz PDF
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2011
A mathematical model for the Zinc response of young pigs ZIB-Report 11-05 Mascha Berg, Julia Ritter, Susanna Röblitz PDF
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A simple mathematical model of the bovine estrous cycle Journal of Theoretical Biology, 278(1), pp. 20-31, 2011 (preprint available as ZIB-Report 10-06) H. Marike T. Boer, Claudia Stötzel, Susanna Röblitz, Peter Deuflhard, Roel F. Veerkamp, Henri Woelders PDF (ZIB-Report)
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BioPARKIN - Biology-related Parameter Identification in Large Kinetic Networks ZIB-Report 11-15 Thomas Dierkes, Moritz Wade, Ulrich Nowak, Susanna Röblitz PDF
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Mechanisms regulating follicle wave patterns in the bovine estrous cycle investigated with a mathematical model Journal of Dairy Science, 94(12), pp. 5987-6000, 2011 H. Marike T. Boer, Susanna Röblitz, Claudia Stötzel, Roel F. Veerkamp, Bas Kemp, Henri Woelders BibTeX
DOI
Soft Versus Hard Metastable Conformations in Molecular Simulations ZIB-Report 11-27 Konstantin Fackeldey, Susanna Röblitz, Olga Scharkoi, Marcus Weber PDF
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2010
Adaptive Spectral Clustering for Conformation Analysis AIP Conference Proceedings, 1281(1), pp. 1585-1588, 2010 Fiete Haack, Susanna Röblitz, Olga Scharkoi, Burkhard Schmidt, Marcus Weber BibTeX
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Computing expectation values for molecular quantum dynamics SIAM Journal on Scientific Computing, 32(3), pp. 1465-1483, 2010 Caroline Lasser, Susanna Röblitz BibTeX
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Mathematical Systems Biology at Zuse Institute Berlin (ZIB) BioTOPics - Journal of Biotechnology in Berlin-Brandenburg, Vol.39, 2010 Peter Deuflhard, Susanna Röblitz, Claudia Stötzel BibTeX
2009
Computing expectation values for molecular quantum dynamics ZIB-Report 09-30 (Appeared in: SIAM J. Sci. Comput. 2010, 32(3), pp. 1465-1483) Caroline Lasser, Susanna Röblitz PDF
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DOI
Fuzzy Spectral Clustering by PCCA+ Classification and Clustering: Models, Software and Applications, pp. 73-79, 2009 Susanna Röblitz, Marcus Weber BibTeX
Statistical Error Estimation and Grid-free Hierarchical Refinement in Conformation Dynamics Doctoral thesis, Freie Universität Berlin, Peter Deuflhard, Wilhelm Huisinga (Advisors), 2009 Susanna Röblitz PDF
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2008
Computation of equilibrium densities in metastable dynamical systems by domain decomposition Numerical Analysis and Applied Mathematics, International Conference on Numerical Analysis and Applied Mathematics 2008, pp. 339-342, Vol.1048, 2008 Susanna Kube, Marcus Weber BibTeX
Monte Carlo sampling of Wigner functions and surface hopping quantum dynamics Journal of Computational Physics, 228(6), pp. 1947-1962, 2008 (preprint available as ZIB-Report 07-17) Susanna Kube, Caroline Lasser, Marcus Weber PDF (ZIB-Report)
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Preserving the Markov Property of Reduced Reversible Markov Chains Numerical Analysis and Applied Mathematics, International Conference on Numerical Analysis and Applied Mathematics 2008, pp. 593-596, Vol.1048, 2008 Susanna Kube, Marcus Weber BibTeX
2007
A Coarse Graining Method for the Identification of Transition rates between Molecular Conformations Journal of Chemical Physics, 126(2), 2007 Susanna Kube, Marcus Weber BibTeX
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Stable Computation of Probability Densities of Metastable Dynamical Systems SIAM J. Multiscale Model. Simul., 6(2), pp. 396-416, 2007 Marcus Weber, Susanna Kube, Lionel Walter, Peter Deuflhard BibTeX
2006
Coarse Grained Molecular Kinetics ZIB-Report 06-35 (Appeared as : "A coarse grained method for the identification of transition rates between molecular conformations" in Journal of Chemical Physics, 126(2) 2007) Susanna Kube, Marcus Weber PDF
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Efficient Sampling of the Stationary Distribution of Metastable Dynamical Systems ZIB-Report 07-03 Marcus Weber, Susanna Kube, Alexander Riemer, Alexander Bujotzek PDF
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Stable computation of probability densities for metastable dynamical systems ZIB-Report 06-39 (Appeared in: SIAM J. Multisc. Mod. Sim. 2007, 6(2), pp. 396-416) Marcus Weber, Lionel Walter, Susanna Kube, Peter Deuflhard PDF
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2005
Conformation Kinetics as a Reduced Model for Transition Pathways ZIB-Report 05-43 Susanna Kube, Marcus Weber PDF
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Identification of Metastabilities in Monomolecular Conformation Kinetics ZIB-Report 06-01 Susanna Kube, Marcus Weber PDF
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Robust Perron Cluster Analysis for Various Applications in Computational Life Science Computational Life Sciences, pp. 57-66, 2005 Marcus Weber, Susanna Kube BibTeX